Aesthetics
Effect of amniotic fluid on hair follicle growth
Results: Both FAF and FAFI treatments significantly increased HF density, with FAFI exhibiting enhanced effects. Histological analysis demonstrated improved HF regeneration, increased M2 macrophages, and reduced collagen fiber deposition in treated areas. Gamma irradiation likely improved the efficacy of FAFI by stabilizing active components and inhibiting protease activity.
Conclusions: Irradiated hAF is a safe and effective therapeutic candidate for alopecia and HF growth disorders. These findings support further evaluation of hAF in clinical trials to validate its potential for hair regeneration therapies.
Amniotic Fluid for Acne Scars
There was significant increase in the improvement percentage of acne scars on right side (dermaroller and AF‐MSC‐CM) vs left side of face (dermaroller; P < 0.001). Histologically, improvement of character of collagen and elastic fibers was noticed, especially on right side. Meanwhile, significant increase in epidermal thickness on both sides of face was detected. Conclusion: Amniotic fluid‐derived mesenchymal stem cell‐conditioned media combined with microneedling is more effective in management of atrophic postacne scars than microneedling alone.
The Effect of Amniotic Fluid on Hair Follicle Growth
Human amniotic fluid stem cell (hAFSC) exhibit significantly as a new treatment modality in hair loss, wound, scar and regenerative plastic surgery/dermatology. The difference of our study from previous amniotic fluid studies on the hair growth model was studied through the direct effect of human amniotic fluid (hAF).
Stem Cells use in Androgenetic Alopecia
During and after treatment with stem cells, no major side effects were reported by patients with alopecia. The use of stem cells in androgenic alopecia seems to be a promising alternative to the standard treatment or it could play the role of complementary therapy to improve the effect of primary treatment. However, these results should be interpreted with caution until they can be reproduced in larger and more representative samples.
Treatment of Atrophic Post Acne Scars
There was a significant increase in the improvement percentage of acne scars on right side (dermarpen and platelet rich plasma gel) than left side of face (dermapen and irradiated amniotic gel). Histologically, improvement of character of collagen and elastic fibers was noticed, especially on right side. Meanwhile, a significant increase in epidermal thickness on both sides of face was detected. Conclusion: Dermapen combined with either plasma gel or amniotic gel are promising effective therapeutic modalities for atrophic acne scars. However, combination of platelet rich plasma gel with dermapen has a higher therapeutic efficacy than that of amniotic gel with dermapen.
Extracellular Vesicles in Facial Aesthetics
In summary, EV therapy reduces scarring, rejuvenates aging skin, and reduces pigmentation. These observations warrant the development of EV-based cosmetic products. However, more efforts are needed to establish a large-scale EV production platform that can consistently produce functional EVs and understand EVs’ underlying mechanism of action to improve their efficacy.