Regenerative Science

Cell-Free Amniotic Fluid and Regenerative Medicine: Current Applications and Future Opportunities

This review summarizes published fundamental, translational, and clinical investigations into the biological activity and potential use of cfAF as a therapeutic agent.

Clinical Uses for Biomedicines

Amniotic fluid (AF) provides critical biological and physical support for the developing fetus. While AF is an excellent source of progenitor cells with regenerative properties, recent investigations indicate that cell-free AF (cfAF), which consists of its soluble components and extracellular vesicles, can also stimulate regenerative and reparative activities.

Exosomes Inflammation and Tissue Repair

We conclude our review with speculations on the mechanism of action of ViX001, the importance of extracellular vesicles in the amniotic fluid for its biological activity, and the need for expanding our studies to generate a better understanding of the omics signature of this incredibly beneficial material.

Amniotic Fluid as a Potential Source of Extracellular Vesicles

Cell therapy, especially with mesenchymal stem cells (MSCs), is a potent treatment for many diseases or disorders. Meanwhile, MSCs-based cell-free products, such as extracellular vesicles (EVs) have been suggested as an alternative to MSCs.

A Comprehensive Review of Stem Cells in Medical Practice

Stem cells are types of cells that have unique ability to self-renew and to differentiate into more than one cell lineage. They are considered building blocks of tissues and organs. Over recent decades, they have been studied and utilized for repair and regenerative medicine.

Regenerative Medicine using Stem Cells

Regenerative medicine is the most recent and emerging branch of medical science that develops methods to regrow, repair or replace damaged or diseased cells, organs, or tissues to restore normal function.